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缺氧是许多肿瘤的特性,缺氧诱导因子1(HIF- 1)在多种肿瘤中广泛存在,可调控一系列靶基因的转录,对于肿瘤多药耐药(MDR)的形成有着多方面的作用。
Hypoxia is a hallmark of many tumors. Hypoxia-inducible factor 1 (HIF-1) is widespread in many tumors and regulates the transcription of a range of target genes and has many implications for the formation of multidrug resistance (MDR) tumors effect.