目的:对比观察增生型糖尿病视网膜病变（PDR）患眼荧光素眼底血管造影（FFA）和扫频源光相干断层扫描血管成像（SS-OCTA）视网膜毛细血管无灌注区面积测量结果。方法:横断面研究。2019年9月至2020年1月于河南省人民医院眼科确诊为PDR的11例患者18只眼纳入研究。采用德国Heidelberg公司Spectralis HRA+OCT行FFA检查，视微影像（河南）科技有限公司VG200D行SS-OCTA检查。SS-OCTA采集视网膜层、浅层毛细血管层（SCP）、深层毛细血管层（DCP）图像。观察范围为以黄斑中心凹为中心，共同呈现于55° FFA图像和80°×60° SS-OCTA图像中且边界清晰的49个片状毛细血管无灌注区。其面积测量由3名测量者独立完成。3名测量者之间两种检查方法测得的毛细血管无灌注区面积比较采用配对样本n t检验或配对样本Wilcoxon检验。n 结果:3名测量者FFA、SS-OCTA测得的视网膜层、SCP、DCP无灌注区面积比较，差异均无统计学意义（n P>0.05），且一致性好（一致性相关系数>0.9，n P 0.9,n P<0.05). The nonperfusion area measured by FFA was 0.786 mmn 2. The median nonperfusion area of retinal layer and SCP measured by SS-OCTA were 0.787 mmn 2 and 0.791 mmn 2, respectively, and the average nonperfusion area of DCP was 0.878±0.366 mmn 2. The nonperfusion area of retinal layer and SCP measured by FFA and SS-OCTA showed no statistically significant difference (n P=0.054, 0.198). The nonperfusion area of DCP measured by SS-OCTA was significantly larger than that of FFA, and the difference was statistically significant (n P<0.001). The results of repeatability analysis showed that 93.88% (46/49) of the DCP nonperfusion area data measured by SS-OCTA were greater than those measured by FFA.n Conclusion:The retinal nonperfusion area of DCP in PDR patients measured by SS-OCTA is larger than that of FFA.