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目的制备载有牛血清白蛋白(BSA)的聚乙烯醇(PVA)微纳纤维,建立一种新型的药物缓释载体。方法将适量的PVA和BSA混合溶液在液氮下快速冷冻,然后冷冻干燥48 h即得载BSA的PVA纤维。运用扫描电子显微镜(SEM)、X-射线粉末衍射(XRD)、差示扫描量热(DSC)等技术对制备的载药纤维进行表征,并对其体外释药动力学进行研究。结果 BSA成功地包载到PVA中,制得的PVA纤维具有较好的稳定性、较高的载药量和100%的包封率。体外释放实验表明BSA在PVA纤维中具有较好的释放度,其释放曲线符合双相动力学方程。结论载药聚合物纤维能够延缓药物的释放,是一种具有潜在应用价值的新型药物缓释载体。
Objective To prepare polyvinyl alcohol (PVA) micro-nanofiber containing bovine serum albumin (BSA) and establish a novel drug delivery carrier. Methods The appropriate amount of PVA and BSA mixed solution was quickly frozen in liquid nitrogen and then freeze-dried for 48 h to obtain PVA fibers of BSA. The prepared drug loaded fibers were characterized by scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). The in vitro drug release kinetics was also studied. Results BSA was successfully encapsulated in PVA. The prepared PVA fiber has better stability, higher drug loading and 100% entrapment efficiency. In vitro release experiments showed that BSA in PVA fiber has a good release, the release curve in line with the biphasic kinetic equation. Conclusion The drug-loaded polymer fiber can delay the release of drug, which is a new drug sustained-release carrier with potential application value.