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患者男性,46岁,西班牙同性恋患者。因右腿及左臀部发生直径大于2cm的持久性痛性角化过度的损害就诊。CD4细胞计数0.2×10~8/L。过去史包括Kaposi肉瘤,杆菌性多发性血管瘤病,隐球菌性脑膜炎,肺囊肿性肺炎,播散性鸟型分支杆菌综合征。曾用二脱氧肌苷、磺胺甲(口恶)唑、甲氧苄啶、氟康唑、乙胺丁醇、苯地芬诺酯及克立霉素(clarithromycin)治疗。皮损培养出VZV,口服阿昔洛韦800mg,每日5次。损害变平,但没有完全消退。再次培养出VZV,由于缺乏胸腺嘧啶核苷激酶,对阿昔洛韦产生抗
Male patient, 46 years old, gay patient in Spain. Due to the right leg and left hip occurred diameter greater than 2cm persistent painful hyperkeratosis treatment. CD4 cell count 0.2 × 10 ~ 8 / L. Past history includes Kaposi’s sarcoma, bacillary polychaete hemangiomatosis, cryptococcal meningitis, pulmonary cystitis, disseminated Mycobacterium avium syndrome. Have been treated with dideoxyinosine, sulfamethoxazole, trimethoprim, fluconazole, ethambutol, benzene diphenoxylate and clarithromycin. VZV lesions were cultured, oral acyclovir 800mg, 5 times a day. The damage flattened, but not completely dissipated. VZV is again cultivated, producing acyclovir due to the lack of thymidine kinase