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目的 探讨应用中药肺积方与放射性12 5I粒子植入结合治疗晚期非小细胞肺癌的疗效和方法。方法 治疗组 10例晚期肺癌患者行放射性12 5I粒子肿瘤内植入治疗 ,植入当天起采用中药肺积方口服。每日 1剂 ,30d为 1个疗程 ;治疗 1个月后复查 ,观察治疗前后生活质量、主要症状改善情况及肿瘤控制情况 ,追踪生存期。结果 治疗后比治疗前大部分 (80 %以上 )患者KPS评分和体质量稳定或提高 ;疲乏、纳差、疼痛等主要症状改善 ;肿瘤控制情况 :CR 1例 ,PR 5例 ,SD 3例 ,PD 1例。(CR +PR)共 6例 ,治疗总有效率为 6 0 % ,稳定率为 30 % ,进展率为10 %。中位生存期 11个月。 1年生存率 5 0 %。结论 中药肺积方与12 5I粒子植入结合治疗中晚期非小细胞肺癌对改善患者生活质量和主要症状、控制肿瘤的增长、延长生存期均有较好疗效。
Objective To investigate the curative effect and method of using traditional Chinese medicine Jifang Recipe combined with radioactive 125I seed implantation in the treatment of advanced non-small cell lung cancer. Methods 10 cases of advanced lung cancer patients treated with radioactive 125I radioactive tumor implantation, the day of implantation from the use of traditional Chinese medicine lung plot side oral. 1 day, 30d for a course of treatment; 1 month after treatment review, observe the quality of life before and after treatment, the main symptoms and tumor control to improve the situation, follow-up survival. Results The KPS score and body weight of most patients (more than 80%) before treatment were stable or improved after treatment. The main symptoms such as fatigue, anorexia and pain were improved. The tumor control was CR 1, PR 5, SD 3, PD 1 case. (CR + PR) in 6 cases, the total effective rate was 60%, the stability rate was 30% and the progress rate was 10%. The median survival of 11 months. 1 year survival rate of 50%. Conclusion Traditional Chinese medicine Fei Ji Fang combined with 125I particle implantation in the treatment of advanced non-small cell lung cancer in improving the quality of life and the main symptoms of patients with control of tumor growth and prolong survival have a good effect.