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目的观察海螵蛸颗粒剂联合血液透析滤过(HDF)与血液灌流(HP)联合血液透析(HD)对维持性血液透析(MHD)患者血清钙磷及甲状旁腺激素水平的影响。方法将符合标准的60例MHD患者随机分为中药+HDF组、HP+HD组,每组各30例。2组均治疗6个月,观察治疗前后血钙、血磷、全段甲状旁腺激素(i PTH)指标的变化。结果治疗后中药+HDF组、HP+HD组血磷及i PTH均较治疗前降低(P<0.05)。中药+HDF组血钙、血磷下降均优于HP+HD组(P<0.05),i PTH下降与HP+HD组比较差异无统计学意义(P>0.05)。结论海螵蛸颗粒剂联合血液透析滤过在降低维持性血液透析患者血磷水平方面较血液灌流联合血液透析更为有效。
Objective To observe the effects of Haiyutang Granule combined with hemodialysis (HDF) and hemoperfusion (HP) combined with hemodialysis (HD) on serum calcium, phosphorus and parathyroid hormone levels in patients with maintenance hemodialysis (MHD). Methods Sixty patients with MHD were randomly divided into TCM + HDF group and HP + HD group, with 30 cases in each group. Both groups were treated for 6 months, and the changes of serum calcium, phosphorus and total parathyroid hormone (i PTH) before and after treatment were observed. Results After treatment, the levels of serum phosphorus and i PTH in TCM + HDF group and HP + HD group were lower than those before treatment (P <0.05). Compared with HP + HD group, the decrease of serum calcium and phosphorus in Chinese medicine + HDF group was not significant (P> 0.05). Conclusions The combination of HAIJI granules and hemodiafiltration is more effective than hemoperfusion in combination with hemodialysis in reducing the level of serum phosphorus in maintenance hemodialysis patients.