目的　介绍应用VX2 细胞株制作兔移植性肝癌模型 ,并用CT、MR等影像学检测手段筛选实验动物 ,评价瘤灶生长情况变化。方法　实验动物为新西兰大白兔 (60只 ) ,瘤株采用动物自身接种传代。VX2 瘤块组织接种于肝左叶 ,40只于接种后 3～ 4周行螺旋CT平扫及增强动态双期扫描、MR扫描 ,并行DSA造影。 2 0只于接种后 5周行上述检查。结果　 5 1只 (85 % )接种成功。CT平扫瘤体为低 /等密度灶 ,动脉期明显增强 ,门脉期呈低密度。MR平扫呈稍长T1、稍长T2 信号。肝动脉造影瘤体富血供 ,由肝动脉供血。注入碘油后可见瘤区碘油沉积。种植后 5周瘤体均有不同程度坏死。结论　移植性兔VX2 肝癌类似人类原发性肝癌 ,是介入治疗实验研究较为理想的动物模型。综合影像评价有利于实验动物的筛选 Objective To introduce a rabbit model of HCC with VX2 cell line and screen the experimental animals with CT and MR imaging methods to evaluate the changes of tumor growth. Methods The experimental animals were New Zealand white rabbits (60 rabbits), the tumor strains were passaged by animals themselves. VX2 tumor tissue was inoculated into the left lobe of the liver and 40 of them were scanned with spiral CT and enhanced dynamic double-phase scanning, MR scanning and DSA angiography 3 to 4 weeks after inoculation. 20 Only 5 weeks after vaccination. Results 5 1 (85%) were vaccinated successfully. The CT scan of the tumor was low / isodense, the arterial phase was significantly enhanced, and the portal phase was low density. MR scan showed a slightly longer T1, slightly longer T2 signal. Hepatic artery angiography rich blood supply, by the hepatic artery blood supply. Into lipiodol visible tumor area lipiodol deposition. Five weeks after planting tumor have varying degrees of necrosis. Conclusion Transplanted rabbit VX2 hepatocellular carcinoma resembles human primary hepatocellular carcinoma, which is an ideal animal model for the experimental study of interventional therapy. Comprehensive imaging evaluation is conducive to the screening of experimental animals