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多烯大环内酯类抗生素是最有效的抗真菌素之一,在临床和食品工业中都得到广泛的应用。本文综述了多年来多烯大环内酯类抗生素的研究成果及进展。包括:多烯大环内酯类抗生素完整的生物合成流程;该类抗生素杀灭真菌核心机制的最新发现;通过生物工程手段对多烯大环内酯类抗生素进行结构改造的研究,目前人们已实现通过有目的性的理性设计,调整生物合成相关基因来获得预期产物;多烯大环内酯类抗生素从属的聚酮类抗生素相关基因的进化方式和特点等。在介绍多烯大环内酯类抗生素各个方面的研究进展的同时,还对多烯大环内酯类抗生素的研究与应用前景进行了展望。
Polycyclic macrolide antibiotics are one of the most effective antifungal agents, and are widely used in clinical and food industries. This review summarizes the research results and progress of polyene macrolide antibiotics over the years. Including the complete biosynthesis of polyene macrolide antibiotics; the latest discovery of such antibiotics to kill fungal core mechanisms; and the structural engineering of polyene macrolide antibiotics through bioengineering, Achieve through the rational design of purpose, adjust biosynthesis related genes to obtain the desired product; polyene macrolide antibiotics subordinate polyketide antibiotic-related genes evolution and characteristics. In the introduction of polyene macrolide antibiotics in various aspects of research progress, but also polyene macrolide antibiotics research prospects and prospects.