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PTEN是1997年发现的具有双重特异性磷酸酶活性的抑癌基因,PTEN基因通过PI3K/Akt途径、MAPK/ERK途径、FAK等途径发挥其脂质磷酸酶和蛋白磷酸酶活性。PTEN基因与乳腺癌关系密切。该文综述了PTEN及其与乳腺癌相关的研究进展。
PTEN is a tumor suppressor gene with double-specific phosphatase activity discovered in 1997. PTEN gene exerts its lipid phosphatase and protein phosphatase activities through PI3K / Akt pathway, MAPK / ERK pathway and FAK pathway. PTEN gene and breast cancer are closely related. This article reviews PTEN and its progress in breast cancer-related research.