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目的:观察小檗碱对高脂饲料所致非酒精性脂肪肝的影响。方法:采用高脂饲料建立大鼠脂肪肝模型,治疗组分别灌胃给予小檗碱100和200 mg/kg。4周后,处死动物,检测肝指数、抗氧化功能、血清及肝脏中脂质含量等指标。结果:小檗碱能改善大鼠肝指数,明显降低血清及肝匀浆中甘油三酯含量,下调血清游离脂肪酸含量,提高肝匀浆超氧化物岐化酶活性。结论:小檗碱对高脂饲料所致大鼠非酒精性脂肪肝具有一定的保护作用,其机制与调节血脂、提高肝脏抗氧化能力有关。
Objective: To observe the effect of berberine on non-alcoholic fatty liver caused by high fat diet. Methods: The model of fatty liver in rats was established by high-fat diet. Berberine 100 and 200 mg / kg were given orally in the treatment group. After 4 weeks, the animals were sacrificed, liver index, anti-oxidant function and lipid content in serum and liver were measured. Results: Berberine can improve rat liver index, significantly reduce triglyceride content in serum and liver homogenate, decrease serum free fatty acid content, and improve liver homogenate superoxide dismutase activity. Conclusion: Berberine can protect non-alcoholic fatty liver in rats induced by high-fat diet. Its mechanism is related to the regulation of blood lipids and the anti-oxidation ability of liver.