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目的应用双抗体夹心酶联免疫吸附试验(ELl SA法),分析胃癌患者血清HMGB-1(高迁移率族蛋白B-1)水平的临床意义。方法使用ELISA法对98例胃癌患者血清HMGB-1水平进行检测,用电化学发光法对血清癌胚抗原(CEA)含量进行测定,并和40例胃良性病变者及40例正常者进行比较。结果胃癌组患者血清中HMGB-1与CEA水平均明显高于正常对照组与胃良性病变组(P<0.01)。和传统肿瘤标志物CEA对比,血清中HMGB-1检测在胃癌早期患者中有良好敏感性(70.6%)与准确性(74.0%),并具有统计学意义(P<0.05)。结论 HMGB-1和胃癌的发生发展密切相关,检测血清中HMGB-1的含量可以提高早期胃癌的诊断水平。
Objective To investigate the clinical significance of serum HMGB-1 (high mobility group box B-1) level in patients with gastric cancer by ELSA assay. Methods The levels of serum HMGB-1 in 98 patients with gastric cancer were detected by ELISA. The levels of serum carcinoembryonic antigen (CEA) were measured by electrochemiluminescence and compared with 40 patients with benign gastric lesions and 40 normal persons. Results Serum levels of HMGB-1 and CEA in gastric cancer patients were significantly higher than those in normal controls and gastric benign lesions (P <0.01). Compared with traditional tumor marker CEA, HMGB-1 detection in serum had good sensitivity (70.6%) and accuracy (74.0%) in early gastric cancer patients with statistical significance (P <0.05). Conclusion HMGB-1 is closely related to the occurrence and development of gastric cancer. The detection of serum HMGB-1 level can improve the diagnosis of early gastric cancer.