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首次对四环素类化合物进行 4位和 7位化学修饰 ,得到了 5个新的四环素系列衍生物 ,用小鼠小脑神经粒细胞评价这些新化合物的生物活性。结果显示其具有中度的神经保护活性且几乎失去了全部抗菌作用
For the first time, tetracyclines were chemically modified at the 4th and 7th positions, and 5 new tetracycline derivatives were obtained. The activity of these new compounds was evaluated using mouse cerebellar neuroblasts. The results show that it has moderate neuroprotective activity and almost lost all antibacterial effects