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以甲基丙烯酸和8-羟基喹啉为配体,合成了甲基丙烯酸-8-羟基喹啉稀土(钕、镧、铕)配合物,采用元素分析、摩尔电导、红外光谱(IR)、紫外光谱(UV)、荧光光谱和热重-差热分析(TG-DTA)手段对配合物的组成和性质进行了表征。此外,采用体外抑菌圈法研究了合成的3种稀土配合物对大肠杆菌和金黄色葡萄球菌的抑菌活性。实验数据确定配合物的组成为Eu L·L2’和REL2·L’(RE=La,Nd,L=甲基丙烯酸L’=8-羟基喹啉),在二甲亚砜溶液中配合物属非电解质,差热-热重分析结果表明合成的配合物热稳定性较配体增强,且Nd(III),Eu(III)配合物具有较强的Nd3+,Eu3+特征线状荧光。通过体外抑菌实验,发现3种稀土配合物作用大肠杆菌和金黄色葡萄球菌后均具有10~12 mm的抑菌圈,说明所合成的配合物对大肠杆菌和金黄色葡萄球菌的生长具有中等的抑制作用,且对大肠杆菌的抑制作用强于金黄色葡萄球菌。稀土配合物的抑菌作用明显强于单独配体,表明形成配合物后,稀土离子与甲基丙烯酸、8-羟基喹啉的协同作用,显著增强了抗菌效果。
The rare earth (neodymium, lanthanum, europium) complexes of 8-hydroxyquinoline were synthesized by using methacrylic acid and 8-hydroxyquinoline as ligands. Elemental analysis, molar conductivity, IR, The composition and properties of the complexes were characterized by UV, FTIR and TG-DTA. In addition, the antibacterial activity of three synthetic rare earth complexes against Escherichia coli and Staphylococcus aureus was studied by inhibition zone method in vitro. Experimental data to determine the composition of the complex EuL · L2 ’and REL2 · L’ (RE = La, Nd, L = methacrylic acid L ’= 8-hydroxyquinoline), in dimethyl sulfoxide solution complexes The results of thermogravimetric analysis and thermogravimetric analysis show that the thermal stability of the synthesized complexes is stronger than that of the ligands, and Nd (III) and Eu (III) complexes have strong linear fluorescence of Nd3 + and Eu3 +. In vitro antibacterial experiments showed that three kinds of rare earth complexes of E. coli and Staphylococcus aureus after 10 ~ 12 mm inhibition zone, indicating that the synthesis of the complex of E. coli and Staphylococcus aureus growth medium Inhibition of Escherichia coli and Escherichia coli stronger than Staphylococcus aureus. The antibacterial activity of the rare earth complexes was significantly stronger than that of the single ligands, indicating that the synergistic effect of the rare earth ions with methacrylic acid and 8-hydroxyquinoline significantly enhanced the antibacterial effect after the complex was formed.