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目的了解邯郸市脑膜炎奈瑟菌的常用抗生素的耐药性,并指导流行性脑脊髓膜炎(简称流脑)的防控工作以及临床用药。方法采用E-test浓度梯度法对邯郸市2009-2013年分离的80株脑膜炎奈瑟菌进行12种抗菌药物的敏感性检测。结果 80株流脑膜炎奈瑟对青霉素、氨苄西林、头孢曲松、头孢噻肟、氯霉素和美洛培南等抗生素均敏感,敏感率达100.00%;对环丙沙星、左氧氟沙星的耐药率达95%以上,而对复方新诺明的耐药率达100.00%。并且对阿奇霉素、利福平和四环素都有不同程度的耐药。结论邯郸市分离得到的80株脑膜炎奈瑟菌对青霉素、氨苄西林、头孢曲松、头孢噻肟、氯霉素和美罗培南普遍敏感,而对复方新诺明、环丙沙星和左氧氟沙星有较高的耐药性。部分菌株对一些抗生素具有耐药性,仍需全面监测其耐药性。
Objective To understand the common antibiotic resistance of Neisseria meningitides in Handan and to guide the prevention and control of epidemic cerebrospinal meningitis (referred to as meningitis) and clinical medication. Methods E-test concentration gradient method was used to test the sensitivity of 12 antimicrobial agents against 80 Neisseria meningitides isolates from 2009 to 2013 in Handan. Results 80 meningitis meningitis were sensitive to antibiotics such as penicillin, ampicillin, ceftriaxone, cefotaxime, chloramphenicol and meropenem, the sensitivity rate was 100.00%. The resistance to ciprofloxacin and levofloxacin Rate of 95% or more, while the cotrimoxazole resistance rate of 100.00%. And azithromycin, rifampin and tetracycline have varying degrees of resistance. Conclusion 80 strains of Neisseria meningitides isolated from Handan City are generally sensitive to penicillin, ampicillin, ceftriaxone, cefotaxime, chloramphenicol and meropenem, but are relatively more sensitive to the combination of cotrimoxazole, ciprofloxacin and levofloxacin High resistance. Some strains are resistant to some antibiotics, and their resistance needs to be fully monitored.