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氧氟沙星为第三代喹诺酮类抗菌消炎药,在《中国药典》2000年版二部中,对氧氟沙星注射液的热原检查仍采用家兔法。为了研究其细菌内毒素检查方法,通过干扰试验,采用凝胶法,使用两个厂家生产的鲎试行多次对比试验,试图确立一个简便准确的氧氟沙星注射液细菌内毒素检查方法。
Ofloxacin for the third generation of quinolone antibacterial anti-inflammatory drugs, in the “Chinese Pharmacopoeia” 2000 edition of two, the ofloxacin injection pyrogen test is still using rabbit method. In order to study its method of bacterial endotoxin test, we tried to establish a simple and accurate method for bacterial endotoxin test by the interference test, the gel method and the use of the two manufacturers’ test.