论文部分内容阅读
目的系统评价酒精干预对大(小)鼠缺血性卒中结局的影响。方法计算机检索PubMed、EMbase、BIOSIS、CNKI、WanFang Data和VIP数据库中关于酒精干预用于缺血性卒中动物模型的研究,检索时间截至2012年6月。按纳入与排除标准筛选文献、提取资料和进行方法学质量评价后,采用RevMan 5.1软件进行Meta分析。结果共纳入8个研究。Meta分析结果显示:与对照组相比,酒精干预组对缺血性卒中的影响无统计学意义[MD=–6.98%,95%CI(–20.38%,6.43%),P=0.31],但低剂量急性酒精干预(≤2 g/kg)可改善缺血性卒中预后[MD=–22.83%,95%CI(–38.77%,–6.89%),P=0.005],而高浓度慢性酒精干预会加重缺血性卒中脑缺血损伤[MD=24.06%,95%CI(10.54%,37.58%),P=0.000 5]。结论低剂量酒精干预对大(小)鼠具有潜在的神经保护作用,高剂量酒精干预则可能加重其脑损伤程度。但应注意,受纳入研究发表偏倚等因素的影响,酒精干预对大(小)鼠卒中结局的影响程度可能被高估。
Objective To evaluate the effect of alcohol on the outcome of ischemic stroke in rats. Methods A computer-based online search of PubMed, EMbase, BIOSIS, CNKI, WanFang Data and VIP databases was conducted to investigate the use of alcohol in animal models of ischemic stroke. The search time was up to June 2012. According to inclusion and exclusion criteria screening of literature, data extraction and methodological quality evaluation, the use of RevMan 5.1 software for meta-analysis. Results A total of eight studies were included. Meta-analysis showed that the alcohol intervention group had no significant effect on ischemic stroke compared with the control group [MD = -6.98%, 95% CI (-20.38%, 6.43%), P = 0.31] Low-dose acute alcohol intervention (≤ 2 g / kg) improved the prognosis of ischemic stroke [MD = -22.83%, 95% CI, -38.77%, -6.89% (24.06%, 95% CI 10.54%, 37.58%, P 0.0005). Conclusions Low-dose alcohol may have potential neuroprotective effect on large and small rats, and high-dose alcohol may aggravate the degree of brain damage. However, it should be noted that the impact of alcohol intervention on the stroke outcome in large and small mice may be overestimated due to factors such as inclusion of research publication bias.