目的观察脂蛋白、钙拮抗剂对大鼠贮脂细胞增殖、透明质酸及胶原合成的影响．方法通过ＭＴＴ法，透明质酸放射免疫分析法及３Ｈ脯氨酸掺入法测定了低密度脂蛋白（ｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎ，ＬＤＬ）、钙拮抗剂尼卡地平（Ｎｉｃａｒｄｉｐｉｎｅ，Ｎｉｃ）和维拉帕米（Ｖｅｒａｐａｍｉｌ，Ｖｅｒ）及其联合应用对大鼠贮脂细胞（ｆａｔｓｔｏｒｉｎｇｃｅｌ，Ｆｓｃ）增殖、透明质酸（ｈｙａｌｕｒｏｎｉｃ，ＨＡ）及胶原合成的影响．结果ＬＤＬ能促进ＦＳＣ增殖、ＨＡ及胶原合成，同时Ｎｉｃ及Ｖｅｒ对ＬＤＬ刺激引起的ＦＳＣ增殖、胶原合成有明显的抑制作用，但对ＨＡ的抑制作用不明显．结论ＬＤＬ参与ＦＳＣ的增殖及细胞外基质的合成，Ｎｉｃ及Ｖｅｒ则有对抗ＬＤＬ的作用 Objective To investigate the effects of lipoprotein and calcium antagonist on the proliferation of lipid-storing cells, hyaluronic acid and collagen synthesis in rats. Methods Lowdensity lipoprotein (LDL), nicardipine (Nicardipine) and verapamil (calcium antagonist) were determined by MTT assay, radioimmunoassay with hyaluronic acid and 3H-proline incorporation Verapamil, Ver) and their combination on proliferation of fatstoringcel (Fsc), hyaluronic acid (HA) and collagen synthesis in rats. Results LDL promoted the proliferation of FSC, HA and collagen synthesis. At the same time, Nic and Ver inhibited the growth of FSC and collagen synthesis induced by LDL, but had no obvious inhibitory effect on HA. Conclusions LDL is involved in the proliferation of FSC and the synthesis of extracellular matrix. Nic and Ver have the anti-LDL effect