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目的:探讨高龄老年人感染铜绿假单胞菌肺炎的抗菌药合理治疗方案。方法:回顾性分析我院铜绿假单胞菌感染的80岁以上老年肺炎患者79例,按治疗目的不同分为症状消失组(A组)和症状消失且细菌学检查转阴组(B组)。比较两组的耐药性变化及不良反应发生情况,平均治疗时间、住院天数和治疗后1周内复发率等指标。结果:与A组比较,B组耐药性、胃肠道反应和二重感染发生率明显增高(P<0.05),平均治疗时间和住院天数显著增加(P<0.01)。两组在治疗后1周内复发率比较差异无统计学意义(P>0.05)。结论:以症状消失为治疗终点更适合80岁以上老年人铜绿假单胞菌肺炎的治疗。
Objective: To investigate the rational treatment of antibacterials in elderly patients with Pseudomonas aeruginosa pneumonia. Methods: A retrospective analysis of 79 cases of Pseudomonas aeruginosa infection in elderly patients over 80 years of age with pneumonia, according to the purpose of treatment was divided into symptoms disappeared group (A group) and symptoms disappeared and bacteriological examination negative group (B group) . The changes of drug resistance and incidence of adverse reactions in the two groups were compared, and the average treatment time, hospitalization days and relapse rate within 1 week after treatment were compared. Results: Compared with group A, the incidence of drug resistance, gastrointestinal reaction and double infection in group B were significantly increased (P <0.05), and the average treatment time and length of hospital stay were significantly increased (P <0.01). There was no significant difference in relapse rate between the two groups within one week after treatment (P> 0.05). Conclusion: The disappearance of symptoms as the treatment end point is more suitable for the treatment of Pseudomonas aeruginosa pneumonia in the elderly over 80 years old.