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用三氧化二砷(As2O3)注射液治疗11例复发和难治急性早幼粒细胞白血病(APL),结果完全缓解(CR)8例(73%),CR后仍用该注射液维持治疗,其中6例持续CR(CCR)已15~33个月。As2O3注射液毒副反应较轻,患者能很好耐受,是治疗复发及难治性APL的一种安全特效药物。
Treatment of 11 patients with relapsed and refractory acute promyelocytic leukemia (APL) with arsenic trioxide (As2O3) injection resulted in complete remission (CR) in 8 patients (73%). After CR treatment was maintained with 6 injections. Sustained CR (CCR) has been 15 to 33 months. As2O3 injection has less toxicity and can be well tolerated by patients. It is a safe and effective drug for the treatment of relapsed and refractory APL.