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目的 探讨前列腺癌根治术中穿刺标本Gleason评分及穿刺阳性针数比例与术后病理切缘阳性之间的相关性.方法 130例经穿刺病理证实的局限性前列腺癌患者行前列腺癌根治术,分析其穿刺后的Gleason评分、穿刺阳性针数比例与术后病理切缘阳性率之间的关系.结果 130例穿刺标本,Gleason评分6分组50例,切缘阳性率为10.00％ (5/50);Gleason评分7分组65例,切缘阳性率为21.54％(14/65);Gleason评分8分组13例,切缘阳性率为0;Gleason评分9分组2例,切缘阳性率为0,不同穿刺标本Gleason评分各组之间切缘阳性率比较差异无统计学意义(x2=5.917 5,P＞ 0.05).穿刺阳性针数比例统计共89例,阳性针数比例1％～ 25％组30例,切缘阳性率为3.33％(1/30);阳性针数比例26％～50％组27例,切缘阳性率为11.11％(3/27);阳性针数比例51％ ～ 75％组18例,切缘阳性率为6/18;阳性针数比例76％～100％组14例,切缘阳性率为4/14,不同穿刺阳性针数比例各组之间切缘阳性率比较差异有统计学意义(x2=9.861 8,P＜ 0.05).结论 前列腺癌穿刺标本Gleason评分与术后病理切缘之间无相关性,而穿刺阳性针数比例与术后病理切缘之间有相关性.“,”Objective To investigate the correlation of positive margins after radical prostatectomy with Gleason score of biopsy specimens and percentage of positive biopsy cores in prostate cancer.Methods One hundred and thirty patients with localized prostate cancer were confirmed by biopsy underwent radical prostatectomy,the relationship between positive margins rate and Gleason scores,percentage of positive biopsy cores were analyzed.Results One hundred and thirty cases of biopsy specimens,Gleason score 6 group 50 cases,positive margins rate was 10.00％ (5/50),Gleason score 7 group 65 cases,positive margins rate was 21.54％(14/65),Gleason score 8 group 13 cases,positive margins rate was 0,Gleason score 9 group 2 cases,positive margins rate was 0,the positive margins rate among the different Gleason score group had no significant difference (x2 =5.917 5,P ＞ 0.05).All the statistics of percentage of positive biopsy cores were 89 cases,1％-25％ group 30 cases,positive margins rate was 3.33％ (1/30),26％-50％ group 27 cases,positive margins rate was 11.11％ (3/27),51％-75％ group 18 cases,positive margins rate was 6/18,76％-100％ group 14 cases,positive margins rate was 4/14,the positive margins rate among different percentage of positive biopsy cores group had significant difference (x2 =9.861 8,P ＜ 0.05).Conclusion There is no correlation between Gleason score and positive margins in prostate cancer,but there is correlation between percentage of positive biopsy cores and positive margins.