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目的:研究胸水中干扰素诱导蛋白10(interferon-inducible protein 10,IP-10)水平对结核性胸膜炎的诊断价值。方法:用ELISA检测43例结核性胸膜炎和33例恶性胸腔积液患者胸水中IP-10水平;绘制受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)确定其诊断结核性胸膜炎的临界值,并评价其敏感性、特异性和诊断效能。结果:结核性胸膜炎组胸水中IP-10含量为(1 095.67±556.29)pg/ml,显著高于恶性胸腔积液组(121.39±61.21)pg/ml,P<0.01。IP-10诊断结核性胸膜炎的临界值为194.5 pg/ml,敏感性和特异性分别为83.7%和97.0%;IP-10的诊断效能与γ-干扰素(IFN-γ)相近。结论:胸水中IP-10水平测定有助于结核性胸膜炎的诊断。
Objective: To investigate the diagnostic value of interferon-inducible protein 10 (IP-10) in pleural effusion to tuberculous pleurisy. Methods: The levels of IP-10 in pleural effusion of 43 patients with tuberculous pleurisy and 33 patients with malignant pleural effusion were detected by ELISA. The receiver operating characteristic curve (ROC curve) was drawn to determine the threshold of diagnosis of tuberculous pleurisy , And evaluated its sensitivity, specificity and diagnostic efficacy. Results: The IP-10 content in tuberculous pleurisy group was (1095.67 ± 556.29) pg / ml, which was significantly higher than that in malignant pleural effusion group (121.39 ± 61.21) pg / ml, P <0.01. The cutoff value of IP-10 in diagnosing tuberculous pleurisy was 194.5 pg / ml, with a sensitivity and specificity of 83.7% and 97.0%, respectively. The diagnostic efficacy of IP-10 was similar to that of interferon-γ (IFN-γ). Conclusion: The determination of IP-10 in pleural effusion contributes to the diagnosis of tuberculous pleurisy.