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目的 比较三种药物治疗晶状体超声乳化术后干眼的效果.方法 前瞻性病例对照研究.以2017年6月至2018年5月郑州大学第一附属医院行超声乳化术后干眼96例(96眼)为研究对象,随机分为A组(小牛血去蛋白提取物眼用凝胶滴眼组)、B组(维生素A棕榈酸酯眼用凝胶滴眼组)和C组(Omega-3脂肪酸滴眼组).分别于术前,术后1个月进行干眼问卷(OSDI)调查、泪膜破裂时间(BUT)检查、角膜荧光染色(FL)和泪液分泌试验(SIt).结果 术后1个月,3组OSDI评分均低于术前,差异有统计学意义(A组,t=60.012,P=0.001;B组,t=51.114,P=0.001;C组,t=39.427,P=0.001).三组间OSDI评分比较,差异无统计学意义(F=5.684,P=0.051).A、C组间BUT、SIt及OSDI评分,均优于B组(P＜0.05).FL评分结果A组优于B、C组(P＜0.05).结论 小牛血去蛋白提取物和Omega-3脂肪酸均可延长BUT,前者对修复角膜上皮更具优势.“,”Objective To compare the clinical efficacy of three drugs in the treatment of dry eye after phacoemulsification.Methods A prospective case-control study.A total of 96 eyes of 96 patients with dry eye after phacoemulsification from Jun.2017 to May 2018 in The First Affiliated Hospital of Zhengzhou University were analyzed.All cases were randomly divided into 3 groups,group A received the deproteinized calf blood extract eye gel,group B received vitamin A palmitate eye gel,and group C received Omega-3 fatty acid drug.Ocular surface disease index questionnaire (OSDI),tear film break-up time (BUT),corneal fluorescence staining (FL) and Schirmer I test (SIt) were performed before and 1 month after operation.Results The OSDI scores of the three groups at 1 month after operation were lower than those before operation.The difference was statistically significant (group A,t =60.012,P =0.001;group B,t =51.114,P =0.001;group C,t=39.427,P=0.001).There was no significant difference among three groups (F=5.684,P=0.051).BUT,SIt and OSDI scores were better in group A and C than those in group B (P＜0.05).FL scores of group A were superior to group B and C,and the difference was statistically significant (P＜0.05).Conclusion Both deproteinized calf blood extract and Omega-3 fatty acid can extend BUT,and the former has more advantage in repairing corneal epithelium.