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目的:分析干扰素联合雾化吸入治疗小儿毛细支气管炎的疗效及对肺功能的影响。方法:将佛山市南海区第六人民医院2014年3月至2016年1月收治的小儿毛细支气管炎患者,随机抽取84例患者平均分为两组,治疗组和对照组各42例。治疗组给予重组人干扰素α2a联合布地奈德混悬液、沙丁胺醇混悬液经雾化吸入;对照组给予布地奈德混悬液+沙丁胺醇混悬液雾化吸入。分析两组患者的治疗效果,用喘息、气促和三凹征等疾病状态的体征改善情况分析效果及治疗前后潮气呼吸肺功能的变化。结果:治疗组显效率95.24%,对照组的85.71%,明显低于治疗组。治疗后两组患者的喘息、气促和三凹征改善症状的程度均显著优于治疗前(P<0.05),而潮气分析肺功能显示治疗组治疗5 d后各指标改善程度显著优于对照组。结论:干扰素联合雾化吸入治疗急性毛细支气管炎的治疗效果良好;并且能较好的改善疾病症状,尤其是早期治疗阶段。
OBJECTIVE: To analyze the curative effect of interferon combined with atomized inhalation on children’s bronchiolitis and its effect on pulmonary function. Methods: A total of 84 patients with pediatric bronchiolitis who were admitted to the Sixth People’s Hospital of Nanhai District of Foshan City from March 2014 to January 2016 were divided into two groups randomly. The treatment group and the control group included 42 patients each. The treatment group was given recombinant interferon α2a combined with budesonide suspension, salbutamol suspension inhalation; control group budesonide suspension + salbutamol suspension inhalation. Analysis of the treatment effect of two groups of patients, with wheezing, shortness of breath and three concave signs and other signs of disease status improvement and analysis of changes before and after treatment of respiratory function changes of moisture. Results: The effective rate was 95.24% in the treatment group and 85.71% in the control group, which was significantly lower than that of the treatment group. After treatment, wheezing, shortness of breath and triple dentition improved symptoms better than those before treatment (P <0.05), while the lung function of moisture analysis showed that the improvement of each index was significantly better than the control group. Conclusion: Interferon combined with inhalation therapy for acute bronchiolitis is effective, and can improve the symptoms of the disease, especially in the early treatment stage.