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目的:回顾发展中国家在治疗视网膜母细胞瘤中的挑战。方法:回顾1998-01/2002-12,埃努古的尼日利亚大学教学医院和Ebrans临床中心的视网膜母细胞瘤患者的临床及组织病理学资料。结果:总共34例通过组织学被确诊为视网膜母细胞瘤患者。男25例(74%),女9例(26%),男女比例为1∶0.4。平均年龄2.9±1.5岁(5mo～7岁)。6例(18%)患者为双眼发病,28例(82%)为单眼。所予以的治疗为眼内容物剜除术或眼球摘除术联合化疗。结论:在发展中国家,由于患者未及时就诊、贫穷、医疗资源匮乏等因素,视网膜母细胞瘤的治疗现状很差。改善其在发展中国家的治疗,应包括健康教育、早期诊断及提供现代化治疗设施。
Objectives: To review the challenges of developing retinoblastoma in developing countries. METHODS: The clinical and histopathological data of patients with retinoblastoma at the Nigerian University Teaching Hospital in Enugu and the Ebrans Clinic were reviewed from January 1998 to February 2002. RESULTS: A total of 34 patients were diagnosed as retinoblastoma by histology. There were 25 males (74%) and 9 females (26%), with a male to female ratio of 1: 0.4. The average age of 2.9 ± 1.5 years (5mo ~ 7 years old). Six patients (18%) had binocular disease and 28 (82%) had monocular disease. The treatment given was ocular content excision or enucleation combined with chemotherapy. CONCLUSION: In developing countries, the treatment of retinoblastoma is poor because of the lack of timely medical treatment, poverty and lack of medical resources. Improving treatment in developing countries should include health education, early diagnosis and provision of modern treatment facilities.