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精神紧张长期以来被认为是冠心病的危险因素之一,也是猝死的促发因素。应激情况下机体常见的反应为儿茶酚胺水平升高。在试管内,肾上腺素为强烈的血小板聚集剂。近年发现血小板膜上存在α_2肾上腺素能受体,提示儿茶酚胺可能直接激活血小板。关于血小板与动脉粥样硬化形成的关系,以往的研究多数系在体外进行。随着对两种血小板分泌蛋白血小板因子4(PF_4)及β血栓球蛋白(βTG)
Mental stress has long been considered as one of the risk factors for coronary heart disease and also as a contributing factor to sudden death. The common reaction in the body under stress is catecholamine levels. In test tubes, epinephrine is a strong platelet aggregation agent. In recent years, the presence of platelet membrane α 2 adrenergic receptors, suggesting that catecholamines may directly activate platelets. About platelet and atherosclerosis, the relationship between the majority of previous studies in vitro. With the release of platelet factor 4 (PF_4) and beta-thromboglobulin (beta-GT) from both platelets,