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目的探讨前降钙素(PCT)指导脓毒症患者抗生素减量或停用时机。方法 93例脓毒症患者分为对照组和治疗组。对照组根据临床表现而观察组用PCT指标,分别指导抗生素应用。结果对照组的二重感染率及病死率明显的大于观察组,观察组抗生素使用时间及费用明显减少,ICU住院时间明显缩短。(P<0.05)。结论用PCT指导抗生素“降阶梯”及停药时机是安全、可靠的。
Objective To investigate whether pre-calcitonin (PCT) can guide antibiotics in sepsis patients or reduce the time of their withdrawal. Methods 93 cases of sepsis patients were divided into control group and treatment group. Control group according to clinical manifestations and observation group with PCT indicators, respectively, to guide the application of antibiotics. Results The double infection rate and mortality in the control group were significantly greater than those in the observation group. The time and cost of antibiotics in the observation group were significantly reduced, and the length of stay in the ICU was significantly shortened. (P <0.05). Conclusions It is safe and reliable to use PCT to guide antibiotics, “step-down” and withdrawal timing.