【摘 要】
：
AIM To detect immunohistochemically the presence of oval cells in chronic viral hepatitis with antibody against c-kit.METHODS We detected oval cells in paraffin
【机 构】
：
Shanghai Institute of Digestive Diseases
论文部分内容阅读
AIM To detect immunohistochemically the presence of oval cells in chronic viral hepatitis with antibody against c-kit.METHODS We detected oval cells in paraffin-embedded liver sections of 3 normal controls and 26 liver samples from patients with chronic viral hepatitis, using immunohistochemistry with antibodies against c-kit, π-class glutathione Stransferase ( Tr-GST ) and cytokeratins 19(CK19).RESULTS Oval cells were not observed in normal livers. In chronic viral hepatitis, hepatic oval cells were located predominantly in the periportal . region and fibrosis septa,characterized by an ovoid nucleus, small size,and scant cytoplasm. Antibody against stem cell factor receptor, c-kit, had higher sensitivity and specificity than π-GST and CK19. About 50% -70% of c-kit positive oval cells were stained positively for either π-GST or CK19.CONCLUSION Oval cells are frequently detected in human livers with chronic viral hepatitis, suggesting that oval cell proliferation is associated with the liver regeneration in this condition.
其他文献
Laryngeal carcinoma is the most common malignancy among head and neck tumors. The purpose of this study is to find biomarkers for laryngeal carcinoma in patient
The general principle for tumor cells to escape from immune surveillance is to prevent tumor antigens from being recognized by the immune system. Many methods h
Objective: To explore the relationship between Shen deficiency and blood stasis. Methods:Using consecutive intramuscular injection of hydrocortisone to build Sh
Arylamine N-acetyltransferases (NATs) are involved in the detoxification of aromatic amines and hydrazine. In order to explore the possible association of NAT2
目的 阐明干扰素γ (IFN-γ)抑制血管内膜增生和防治经皮冠状动脉成形(PTCA)术后再狭窄的体内机制。方法 建立兔再狭窄血管模型，动态观察体内给予重组干扰素γ (IFN-γ)对损
目的 回顾性分析自体外周血干细胞移植(APBSCT)治疗血液恶性病及实体瘤的疗效。方法 51例患血液及实体肿瘤患者接受自体外周血干细胞移植，本文就移植过程中干细胞采集时间、
Aim: To find out the effect of lindane on testicular antioxidant system and testicular steroidogenesis in adult male rats. Methods: Adult male rats were orally
目的 了解绝经后妇女卵巢囊性成熟型畸胎瘤的发生率、恶变率、诊断及处理。方法 从1977年1月至1997年1月共收治绝经后卵巢囊性成熟型畸胎瘤20例，进行回顾性分析。结果 绝经
目的 中国心脏研究-Ⅰ(CCS-1)入选15 000例急性心肌梗塞(AMI)(发病36小时内)患者，随机口服卡托普利或安慰剂治疗4周。结果卡托普利治疗组4周病死率(9.12%)较安慰剂对照组(9.7
目的 探讨维生素A促进免疫细胞功能的机理。方法 采用逆转录－聚合酶链反应，检测分析视黄酸(RA)对体外培养的脐血淋巴细胞（CBL）胰岛素样生长因子1（IGF-Ⅰ）及两类受体（IGF-IR, IGF-I