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目的:改善复方穿心莲颗粒的口感,研究适合儿童服用的掩味混悬颗粒制备工艺。方法:采用流化床底喷工艺制备掩味颗粒,以脱水穿心莲内酯溶出度检测与口感打分、沉降容积为指标,评价掩味混悬颗粒的掩味效果。结果:尤特奇E100作包衣材料,对复方穿心莲颗粒有很好的掩味效果,制备的掩味混悬颗粒在水中分散均匀,口感良好。结论:颗粒包衣工艺掩味效果佳,制备的掩味混悬颗粒适合儿童患者服用。
OBJECTIVE: To improve the taste of Compound Chuanxinlian Granules and to study the preparation process of taste-masked suspension granules suitable for children. Methods: The taste-masking granules were prepared by fluidized bed bottom spray process. The taste-masking effect of taste-masking suspension granules was evaluated by the dissolution test of dehydroandrographolide and the score and sedimentation volume. Results: Eutech E100 was used as the coating material, which had a good taste-masking effect on the compound andrographis paniculata granules. The prepared taste-masking suspension granules were uniformly dispersed in water and had a good taste. CONCLUSION: The particle coating process has a good taste-masking effect and the taste-masked suspended particles prepared are suitable for children patients.