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目的探讨川芎嗪联合依那普利治疗早期糖尿病肾病的疗效及安全性。方法将本院120例早期DN患者随机分为治疗组及对照组,对照组采用常规治疗,治疗组在对照组基础上加用川芎嗪和依那普利。结果治疗组的总有效率93.3%,显著高于对照组的75.0%,差异有统计学意义(P<0.05),两组均未见出血、皮疹及呼吸困难病例。结论川芎嗪与依那普利联用治疗早期DN,能起相互协同增效作用,防止DN的进一步恶化,值得临床推广应用。
Objective To investigate the efficacy and safety of ligustrazine plus enalapril in the treatment of early diabetic nephropathy. Methods A total of 120 patients with early DN in our hospital were randomly divided into treatment group and control group. The control group was treated with conventional therapy. The treatment group was given tetramethylpyrazine and enalapril on the basis of the control group. Results The total effective rate in the treatment group was 93.3%, which was significantly higher than that in the control group (75.0%), the difference was statistically significant (P <0.05). No bleeding, rash and dyspnea were found in both groups. Conclusion Ligustrazine combined with enalapril treatment of early DN, can play a synergistic synergistic effect to prevent further deterioration of DN, it is worth promoting the clinical application.