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为探明云锡矿工肺癌的致病因子,我们同中国预防医学科学院劳动卫生与职业病研究所合作,对我国9种不同踢矿、不同含砷量的矿尘作了诱癌实验研究。 材料与方法 实验动物 由中国医学科学院实验动物研究所提供。采用3月龄、体重180～220g Wistar雌、雄性大鼠610只。实验分组和剂量见表。 粉尘制备 矿石经粉碎后,用金属球磨机和玛瑙乳钵研磨,使粉尘粒径90%以上小于10μm,将各种矿尘和测试物质配成生理盐水混悬液,于染尘前1天高压灭菌并加入青霉素(每只动物2,000单位)。
In order to explore the causative factors of lung cancer in Yun Tin miners, we cooperated with the Institute of Occupational Health and Occupational Diseases, Chinese Academy of Preventive Medicine to make experimental studies on the carcinogenicity of nine kinds of mine dust with different amounts of arsenic in our country. Materials and Methods Experimental animals provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences. Using 3 months old, weighing 180 ~ 220g Wistar female and male rats 610. The experimental group and dose table. Dust prepared ore crushed with a metal ball mill and agate mortar grinding so that the dust particle size more than 90% less than 10μm, all kinds of mineral dust and test substance dubbed saline suspension 1 day before the dimming dust Bacteria and penicillin (2,000 units per animal).