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目的：应用注入腺苷的前质—硫酸腺嘌呤复制的大鼠心脏预处理与经典缺血预处理的对比观察，探讨腺苷预处理效应。方法：实验采用体重为２５０～３００ｇ雄性ＳＤ大鼠４８只，分４组，每组１２只，即正常对照组（ＮＣ组）；缺血再灌组（Ｉ／Ｒ组）；经典缺血预处理组（ＩＰＣ组）；硫酸腺嘌呤预处理组（ＡＳＰＣ组）。通过图像分析测算Ｃａ２＋·Ｍｇ２＋ＡＴＰａｓｅ活性及心肌梗塞范围。结果：ＩＰＣ、ＡＳＰＣ组Ｃａ２＋·Ｍｇ２＋ＡＴＰａｓｅ活性较Ｉ／Ｒ组明显升高（Ｐ＜００１），梗塞面积较Ｉ／Ｒ组明显缩小（Ｐ＜００１）。结论：硫酸腺嘌呤注入大鼠可显示出经典预处理的类似效应。
OBJECTIVE: To investigate the effect of adenosine preconditioning on preconditioning of ischemic preconditioning and ischemic preconditioning in rats preconditioned with adenosine sulphate. Methods: Forty-eight male Sprague-Dawley rats weighing 250-300g were divided into 4 groups (n = 12): normal control group (NC group); ischemia / reperfusion group Treatment group (IPC group); adenine sulfate pretreatment group (ASPC group). Calculate the activity of Ca2 + · Mg2 + ATPase and the extent of myocardial infarction by image analysis. Results: Compared with I / R group, the activity of Ca2 +. Mg2 + ATPase in IPC and ASPC groups was significantly higher than that in I / R group (P <001). The infarct area was significantly smaller than that in I / R group (P <001). CONCLUSION: Adenine sulfate injection in rats shows a similar effect of classical pretreatment.