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目的观察并分析金双歧联合丁螺环酮治疗肠易激综合征的临床疗效。方法对80例门诊患者,年龄在18～70岁,采用随机数字表法,分为治疗组40例,采用金双歧联合丁螺环酮治疗;对照组40例,采用单用金双歧治疗,两组其他内科常规治疗相同,疗程4周,评估两组治疗前后临床疗效及汉密尔登焦虑(HAMA)和汉密尔登抑郁(HAMD)量表评分变化。结果治疗前,两组IBS症状、肠外症状、生活质量、汉密尔登焦虑和抑郁量表评分比较差异无统计学意义。治疗后两组IBS症状、肠外症状、生活质量治疗后均较治疗前明显改善,联合治疗组较单用金双歧组更显著。汉密尔登焦虑和抑郁量表评分两药联合治疗后显著改善,但单用金双歧无明显改善。结论金双歧联合丁螺环酮治疗肠易激综合征,安全、有效、不良反应少。
Objective To observe and analyze the clinical efficacy of Jinshuangqi combined with buspirone in the treatment of irritable bowel syndrome. Methods A total of 80 outpatients, aged from 18 to 70 years old, were randomly divided into treatment group (40 cases) treated with Jinshuangqi combined with buspirone. Control group (40 cases) The same routine medical treatment, the course of 4 weeks, before and after treatment to assess the clinical efficacy and the Hamilton Anxiety (HAMA) and Hamilton Depression (HAMD) scale score changes. Results Before treatment, there was no significant difference in IBS symptoms, extraintestinal symptoms, quality of life, Hamilton Anxiety and Depression Scale between the two groups. After treatment, IBS symptoms, extraintestinal symptoms and quality of life in both groups were significantly improved after treatment compared with those before treatment, and the combined treatment group was more significant than the single Jinshuangqi group. The Hamilton Anxiety and Depression Scale improved significantly after treatment with the combination of two drugs, but no significant improvement was found with gold bilobal alone. Conclusion Jinshuangqi combined buspirone treatment of irritable bowel syndrome, safe, effective, fewer adverse reactions.