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将樟柳碱注入家兔侧脑室,可引起翻正反射消失,皮层自发电活动呈现不规则高幅慢波,表明该药有中枢抑制作用。在一定剂量范围内,剂量加大,抑制作用增强,维持时间延长。毒扁豆碱、去甲肾上腺素、肾上腺素能拮抗樟柳碱的中枢抑制作用,而苄胺唑啉则与之有协同作用。结果提示樟柳碱的中枢抑制作用,不仅与其抗胆碱作用有关,还可能与其抗肾上腺素能作用有一定关系。
Will anisodine injected into the lateral ventricle of rabbits, can cause the right reflex disappeared, cortical spontaneous activity showed irregular high amplitude slow wave, indicating that the drug has a central inhibitory effect. In a certain dose range, the dose increased, the inhibitory effect increased, maintaining time. Physostigmine, norepinephrine and adrenergic antagonize the central inhibitory effect of anisodine, while the benzylazoline has a synergistic effect. The results suggest that anisodine central inhibitory effect, not only with its anticholinergic effects, but also may be related to its anti-adrenergic effect.