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目的探讨一氧化碳中毒患者血小板α-颗粒膜蛋白-140(GMP-140)、血浆血栓烷B2(TXB2)、血液流变学变化及其临床意义。方法选取2013年5月—2014年3月赣南医学院第一附属医院收治的一氧化碳中毒患者174例为研究对象(病例组),根据治疗结果分为迟发性脑病组96例和痊愈组78例。选取同时期体检健康者74例为对照组。比较对照组、病例组治疗前GMP-140、TXB2、血液流变学指标和对照组、迟发性脑病组、痊愈组治疗后GMP-140、TXB2、血液流变学指标。结果病例组患者治疗前GMP-140、TXB2、血液流变指标均高于对照组,差异有统计学意义(P<0.05)。治疗后迟发性脑病组患者GMP-140、TXB2、血液流变学指标均高于对照组和痊愈组,差异有统计学意义(P<0.05)。结论一氧化碳中毒患者GMP-140、TXB2越高,血小板聚集活性越大,预后越差;治疗前后GMP-14、TXB2、血液流变学变化对预测一氧化碳中毒迟发性脑病有提示价值。
Objective To investigate the changes of platelet α-granule membrane protein-140 (GMP-140), plasma TXB2 and hemorheology in patients with carbon monoxide poisoning and its clinical significance. Methods A total of 174 patients with carbon monoxide poisoning admitted to the First Affiliated Hospital of Gannan Medical College from May 2013 to March 2014 were selected as study subjects (case group). According to the results of treatment, 96 patients were divided into delayed encephalopathy group and 78 example. Select the same time the physical examination of 74 cases as control group. The levels of GMP-140, TXB2 and hemorheology in control group and case group before treatment were compared with those in control group, delayed encephalopathy group and recovery group. Results Before treatment, GMP-140, TXB2 and hemorrheological indexes of patients in treatment group were significantly higher than those in control group (P <0.05). The levels of GMP-140, TXB2 and hemorheology in patients with delayed encephalopathy after treatment were significantly higher than those in control group and recovery group (P <0.05). Conclusions The higher GMP-140 and TXB2 in patients with carbon monoxide poisoning, the higher the platelet aggregation activity and the poorer the prognosis are. The changes of GMP-14, TXB2 and hemorheology before and after treatment are valuable in predicting delayed encephalopathy after carbon monoxide poisoning.