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目的研究奥丹色酮对蛙心室有效不应期及相对不应期的影响。方法牛蛙在体蛙心灌流。结果低于１０－３μｍｏｌ／Ｌ浓度的奥丹色酮对蛙心室有效不应期及相对不应期均无明显影响（Ｐ＞０．０５）。起始有效浓度为１０－３μｍｏｌ／Ｌ，在１０－３～１０μｍｏｌ／Ｌ范围内，对有效不应期无明显影响，但显著延长相对不应期（Ｐ＜０．０１），且呈剂量依赖性及时间依从性关系。结论奥丹色酮具有延长蛙心室相对不应期的作用。
Objective To study the effect of oridon ketone on the effective refractory period and the relative refractory period in frog ventricles. Method Bullfrog in frog heart perfusion. The results below the 10-3μmol / L concentration of prostaglandin frog ventricular effective refractory period and the relative refractory period had no significant effect (P> 0.05). The initial effective concentration of 10-3μmol / L, in the range of 10-3 ~ 10μmol / L had no significant effect on the effective refractory period, but significantly prolonged the relative refractory period (P <0.01) and in a dose-dependent manner Sexual and time-dependent relationship. Conclusion Ondanserone has the effect of prolonging the relative refractory period of frog ventricular.