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以4,4’-二氨基二苯甲烷四缩水甘油胺为原料,通过两步法合成制备了一系列不同季铵化度(20%、40%、60%、80%、100%)的多季铵盐抗菌剂,利用红外、核磁共振氢谱对其进行分析和表征,并测定其临界胶束浓度(CMC)、临界表面张力(γCMC)、最小抑菌浓度(MIC)、最小杀菌浓度(MBC)等。研究结果表明,随着季铵化度的增大,临界胶束浓度和临界表面张力减小,抗菌性增强,且都优于常规型抗菌剂十二烷基二甲基苄基氯化铵。季铵化度为100%的多季铵盐B-100的CMC为10.22 g/L,γCMC为29.46 m N/m,对金色葡萄球菌的MIC为7.813μg/m L,对大肠杆菌的MIC为15.625μg/m L,对金色葡萄球菌的MBC为15.625μg/m L,对大肠杆菌的MBC为31.25μg/m L。该抗菌剂可应用于织物、地板、卫生间、家电、汽车等抗菌装饰材料。
Using 4,4’-diaminodiphenylmethane tetraglycidyl amine as raw material, we prepared a series of polyimides with different degrees of quaternization (20%, 40%, 60%, 80%, 100%) by a two- Quaternary ammonium salt antibacterial agents were synthesized and characterized by IR and 1H-NMR. The critical micelle concentration (CMC), the critical surface tension (γCMC), the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration MBC) and so on. The results showed that with the increase of quaternization, the critical micelle concentration and critical surface tension decreased, and the antimicrobial activity increased. Both of them were superior to the conventional antibacterial agent dodecyl dimethyl benzyl ammonium chloride. The CMC of the quaternary ammonium salt B-100 with the quaternization degree of 100% was 10.22 g / L, the γCMC was 29.46 mN / m, the MIC for Staphylococcus aureus was 7.813 μg / mL, the MIC for E. coli 15.625 μg / m L, MBC of S. aureus was 15.625 μg / mL and MBC of E. coli was 31.25 μg / mL. The antibacterial agent can be applied to fabric, flooring, bathroom, household appliances, automobiles and other antibacterial decorative materials.