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目的:研究K-01对血小板聚集与血栓形成的影响。方法:以比浊法测定K-01对大鼠血小板聚集的影响;通过血小板黏附性实验、大鼠体外血栓形成实验、采用大鼠动-静脉旁路血栓形成模型、血液流变性实验,观察K-01对血栓形成相关指标的影响。结果:K-01灌胃(ig)给药,对花生四烯酸(AA),二磷酸腺苷(ADP)诱导的大鼠血小板聚集有明显抑制作用;能明显降低血小板黏附性,量效关系明显;能明显降低体外血栓的湿重;对动-静脉旁路血栓形成有明显抑制作用;K-01各剂量组能显著降低全血黏度及血浆黏度。结论:K-01能明显抑制血小板聚集与大鼠血栓形成。
Objective: To investigate the effect of K-01 on platelet aggregation and thrombosis. Methods: The effect of K-01 on platelet aggregation was determined by turbidimetry. The platelet adhesion test, rat thrombosis in vitro, the model of rat veno-venous bypass thrombosis, -01 on thrombosis-related indicators. Results: Administration of K-01 intragastrically (ig) significantly inhibited the platelet aggregation induced by arachidonic acid (AA) and adenosine diphosphate (ADP) in rats. It could significantly reduce the platelet adhesion and the dose-response relationship Obviously decreased the wet weight of thrombus in vitro, inhibited the arterio-venous bypass thrombosis obviously. K-01 dose group could significantly reduce whole blood viscosity and plasma viscosity. Conclusion: K-01 can significantly inhibit platelet aggregation and thrombosis in rats.