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目的:了解安徽省淮南市12 295人无偿献血者的梅毒感染现状，为公共卫生管理工作提供参考依据。方法:收集淮南市中心血站2017年4月1日至2017年9月30日的无偿献血者12 295人血标本，采用酶联免疫吸附测定法进行梅毒螺旋体(TP)抗体筛检，采用梅毒螺旋体颗粒凝集试验(TPPA)对TP抗体筛检不合格献血者标本进行梅毒确认试验。结果:淮南市12 295人无偿献血者中TPPA阳性48人，TPPA阳性率为3.90‰(48/12 295)；男性献血者TPPA阳性率3.12‰(22/7 048)、女性4.96‰(26/5 247)，差异无统计学意义(n u＝1.61，n P>0.05)；已婚献血者TPPA阳性率5.33‰(42/7 884)、未婚2.01‰(6/2 989)，差异有统计学意义(n u＝2.33，n P0.05). There was statistically significant difference in the TPPA positive rate of the different marriage blood donors[married 5.33‰(42/7 884) vs.unmarried 2.01‰(6/2 989)] in Huainan area(n u=2.33, n P<0.05). There was statistically significant difference in the TPPA positive rate of the blood donors among different education level in Huainan area(χn 2=29.94, n P0.05).n Conclusion:There are significant differences in the TPPA positive rates of the blood donors among marital status and education level in Huainan area.