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目的观察芪参益气滴丸联合前列地尔治疗对糖尿病肾病(DN)患者胱抑素C(Cysc)、24h尿微量白蛋白的影响。方法将60例2型糖尿病(DM)合并DN患者随机分成治疗组(A组)30例,对照组(B组)30例,A组在给予常规治疗基础上,再给予前列地尔10μg加生理盐水100ml静滴,1次/d,并口服芪参益气滴丸0.5g/次,3次/d,治疗14d为一疗程。测定二组治疗前及治疗后Cysc、24h尿微量白蛋白水平。结果 A组治疗后Cysc、24h尿微量白蛋白与B组比较明显降低。结论芪参益气滴丸联合前列地尔可显著降低DN患者Cysc浓度及24h尿微量白蛋白水平,改善和保护肾功能。
Objective To observe the effect of Qishen Yiqi Dropping Pill combined with alprostadil on cystatin C (Cysc) and 24h urinary albumin in patients with diabetic nephropathy (DN). Methods Sixty patients with type 2 diabetes mellitus (DM) combined with DN were randomly divided into treatment group (A group) 30 cases, control group (B group) 30 cases. Group A was given routine treatment, and then given alprostadil 10μg plus physiology Saline 100ml intravenous infusion, 1 times / d, and oral Qi Qisheng Yiqi pills 0.5g / time, 3 times / d, 14d for a course of treatment. Determination of two groups before treatment and after treatment Cysc, 24h urinary albumin levels. Results After treatment, the levels of Cysc and 24h urinary albumin in group A were significantly lower than those in group B. Conclusion Qishenyiqi dropping pills combined with alprostadil can significantly reduce the Cysc concentration in patients with DN and 24h urinary albumin levels to improve and protect renal function.