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近年来，我国恶性肿瘤的发病率和死亡率逐年上升，给家庭和社会造成了严重的经济负担。因此，对恶性肿瘤发生发展的分子机制及新型诊疗方法的研究迫在眉睫。Foxf1毗连非编码发育调控RNA（FENDRR）是近年来发现的长链非编码RNA（LncRNA），其异常表达可通过不同的机制调节细胞的增殖、迁移和侵袭等生物学行为，参与多种恶性肿瘤的发生发展。文章就FENDRR在不同恶性肿瘤中的生物学功能及分子机制研究进展进行综述。“,”In recent years, the morbidity and mortality of malignant tumors in China have been increased year by year, which has caused a serious economic burden on families and society. Therefore, researches of the mechanism of cancer development and new methods of diagnosis and treatment are desperately needed. Foxf1 adjacent non-coding developmental regulatory RNA (FENDRR) is a long non-coding RNA (LncRNA) discovered in recent years. Its abnormal expression can regulate cell proliferation, migration and invasion through different mechanisms, and participate in the development of various malignant tumors. This article reviews the progress of biological functions and molecular mechanisms of FENDRR in different malignancies.