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1983年6～9月,以随机抽样方法对蚌埠市东、中、西三区二十三个居委会0～14岁的6762名儿童进行身长发育与智能检查,发现各类畸形儿童166例,患病率为24.55‰。本文在此基础上,于1986年3～12月,对上述畸形儿童进行病例一对照研究,即将畸形儿童与正常儿童按1:1组成对子、两组的性别、年龄、民族、文化程度相同,住址邻近。按统一的调查方法,对生育史、孕期服药史、患病史、职业史等30余因素进行访视和调查。由于拆迁等原因,调查了68对,获得资料采用单因素和Logistic回归方法进行分析。 结果:单因素分析发现影响畸形的因素有:母亲生育年龄大于35岁、多次怀孕史,经济收入低、抚养人与营养状况等(X~2值均大于3.84,P<0.05)。将上述30余个因素作为变量、使用条件Logistic回归模型,采用Basic语言,在APPleⅡ型微机上运算,最终进入方程的为文化程度X_3(G=4.94,P<0.05),孕期患病X_(12),(高热、流感、风疹、贫血、肝炎等,G=7.52,P<0.01),孕期服药X_(16)(解热镇痛药、镇静止吐药、激素类、抗生素等,G=6.54,P<0.05)与喂养方式X_(20)(G=5.68,P<0.05)等四个因素(见附表)。由此可见妇女怀孕期间预防病毒性感染,慎用上述药物,提倡母乳喂养等是预防儿童发生畸形的有力措施。(附表转53页)。
From June to September 1983, 6762 children from 0 to 14 years of age in 23 districts of East, Central and Western districts of Bengbu were examined for their height and intelligence by random sampling. 166 children with various malformations The prevalence was 24.55 ‰. Based on this, from March to December 1986, a case-control study was conducted on the children with deformity, which means that the deformity children would be paired with the normal children according to 1: 1 ratio. The two groups had the same gender, age, nationality and education level , Near the address. According to a uniform survey method, more than 30 factors such as birth history, medication history during pregnancy, history of illness and occupation history were surveyed and investigated. As a result of demolition and other reasons, 68 pairs of surveyed, access to information using single factor and Logistic regression analysis. Results: Univariate analysis found that the factors that affected deformity were as follows: maternal age greater than 35 years old, multiple pregnancy history, low economic income, dependents and nutritional status (X ~ 2 values were greater than 3.84, P <0.05). The above 30 factors were used as variables, Logistic regression model was used, and Basic language was used to calculate on the APPle Ⅱ microcomputer. The final educational level was X_3 (G = 4.94, P <0.05) (G = 7.52, P <0.01), taking X_ (16) during pregnancy (antipyretic and analgesic drugs, sedative and antiemetic drugs, hormones and antibiotics, etc.) , P <0.05) and feeding mode X_ (20) (G = 5.68, P <0.05). This shows that women during pregnancy to prevent viral infections, with caution in the above-mentioned drugs, to promote breastfeeding is to prevent the occurrence of deformities in children powerful measures. (Schedule go page 53).