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目的探讨长春瑞滨联合顺铂治疗中晚期乳腺癌的临床效果及不良反应发生情况。方法选取2012年1月-2015年1月医院收治的中晚期未行手术治疗的乳腺癌患者72例,根据入院先后分为对照组与观察组各36例。对照组给予顺铂、叶酸钙、5-氟尿嘧啶治疗,观察组给予长春瑞滨联合顺铂治疗,比较2组治疗效果及不良反应发生情况。结果观察组治疗总有效率为83.3%明显高于对照组的63.9%,差异有统计学意义(P<0.05)。观察组恶心、呕吐发生率明显高于对照组,差异有统计学意义(P<0.05);2组静脉炎、脱发、贫血、白细胞降低、血小板降低、肝肾功能异常的发生率比较差异无统计学意义(P>0.05)。结论长春瑞滨联合顺铂治疗乳腺癌的临床效果显著,可有效提升治疗效果,除胃肠道不良反应有所增加外,其余不良反应未见增加,临床治疗时应联合止吐药使用,以提高患者的耐受性。
Objective To investigate the clinical effects and adverse reactions of vinorelbine and cisplatin in the treatment of advanced breast cancer. Methods From January 2012 to January 2015, 72 patients with breast cancer who had not undergone surgery in the middle and late stages were selected. According to the admission, 36 patients were divided into control group and observation group. The control group was treated with cisplatin, calcium folinate, and 5-fluorouracil. The observation group was treated with vinorelbine and cisplatin. The treatment effects and adverse reactions of the two groups were compared. Results The total effective rate in the observation group was 83.3%, which was significantly higher than that in the control group (63.9%). The difference was statistically significant (P<0.05). The incidence of nausea and vomiting in the observation group was significantly higher than that in the control group (P<0.05); there was no statistical difference in the incidence of phlebitis, alopecia, anemia, leukopenia, platelet decrease, and abnormal liver and kidney function in the 2 groups. Significance (P>0.05). Conclusions The clinical effect of vinorelbine combined with cisplatin in treating breast cancer is significant, which can effectively improve the therapeutic effect. In addition to the increase in gastrointestinal adverse reactions, the other adverse reactions have not increased, and clinical antibiotics should be used in combination with antiemetic drugs. Improve patient’s tolerance.