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在构建3株人Ⅰ型免疫缺陷病毒（HIV－1）Gag基因重组痘苗病毒的基础上，实现了Gag蛋白的高效表达，3株重组病毒在感染细胞中表达量分别为14．7、6．0和4.5μg／106细胞／20h，接近杆状病毒的表达水平。表达的重组蛋白可形成病毒样粒子（VLP），并可诱导小鼠产生抗HIV抗体。
Based on the constructed recombinant GIV recombinant vaccinia virus of human immunodeficiency virus type 1 (HIV-1), Gag protein was efficiently expressed. The expression levels of the three recombinant viruses in infected cells were 14.7 and 6 respectively. 0 and 4.5μg / 106cells / 20h, close to the baculovirus expression level. The expressed recombinant protein can form virus-like particles (VLPs) and can induce the mouse to develop anti-HIV antibodies.