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目的:比较高危型人乳头瘤病毒HC2-HPV-DNA检测与薄层液基细胞学(ThinPrep cytology test,TCT)检查在宫颈癌及癌前病变筛查中的应用价值。方法:对本院妇科门诊分别做HC2-HPV-DNA检测与TCT检查并有活检资料者以及同时做HC2-HPV-DNA检测与TCT检查者进行回顾性研究。细胞学诊断标准按照TBS(2001)分类。HC2-HPV-DNA检测以高危型病毒量RLU/CO>1.0为阳性,TCT诊断≥ASCUS为阳性,宫颈活检病理诊断≥CINI为阳性。结果:高危型HC2-HPV-DNA检测对活检诊断≥CINI宫颈病变的敏感度为72.22%,特异度58.54%,TCT检查对活检诊断≥CINI宫颈病变的敏感度为54.21%,特异度66.43%,高危型HC2-HPV-DNA检测敏感性较TCT高,而TCT检查特异性较高危型HC2-HPV-DNA检测好,统计学有显著性差异。结论:高危型HPV的HC2-HPV-DNA检测在宫颈癌及癌前病变筛查中的敏感性较高,是一种有效的筛查手段;TCT检查简单实用且特异性较好;适当时候二者结合运用可提高宫颈癌筛查的阳性率。
Objective: To compare the value of HC2-HPV-DNA test and ThinPrep cytology test (TCT) in the screening of cervical cancer and precancerous lesions. Methods: A retrospective study was conducted on HC2-HPV-DNA and TCT in gynecology clinics of our hospital with biopsy data and HC2-HPV-DNA and TCT tests. Cytology diagnostic criteria according to TBS (2001) classification. The detection of HC2-HPV-DNA was positive for high-risk virus (RLU / CO> 1.0), positive for TCT≥ASCUS, positive for cervical biopsy≥CINI. Results: The sensitivity of high-risk HC2-HPV-DNA test was 72.22% and specificity of 58.54% for biopsy diagnosis of cervical lesions ≥CINI. The sensitivity and specificity of TCT were 54.21% and 66.43% respectively, The sensitivity of high-risk HC2-HPV-DNA test was higher than that of TCT, while the detection of HCT-HC-HPV-DNA of high-risk TCT test was statistically significant. Conclusion: HC2-HPV-DNA detection of high-risk HPV is more sensitive in the screening of cervical cancer and precancerous lesions, which is an effective screening method; TCT is simple and practical and has good specificity; when appropriate, Combined use can improve the positive rate of cervical cancer screening.