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目的 :通过观察静力性和动力性运动对大鼠心脏内分泌激素和内源性一氧化氮 (NO)的影响 ,探讨内分泌激素和NO在运动心脏形成中的作用。方法 :40只SD大鼠随机分成三组 :耐力训练组、静力训练组和对照组。耐力训练组进行 8周的 70 %～ 80 %VO2 max的跑台训练 ,静力训练组进行 8周的抗自身体重的爬杆训练。结果 :(1 )与对照组比耐力训练组的心系数 (心脏重量 /体重 )显著增加 (P <0 0 5) ,心钠素水平升高非常显著 (P <0 0 1 ) ,心脏NO含量及NOS活性均显著增加(P <0 0 5)。 (2 )静力组的心脏系数显著增加 ,心肌组织的血管紧张素水平显著增加 (P <0 0 5)。结论 :运动使心脏内分泌激素和内源性NO发生适应性变化 ,从而对运动心脏的形成发生调节作用 ,其变化因运动方式不同而有所不同
Objective: To observe the effect of static and dynamic exercise on endocrine hormones and endogenous nitric oxide (NO) in rats heart and to explore the role of endocrine hormones and NO in the formation of exercise heart. Methods: Forty SD rats were randomly divided into three groups: endurance training group, static training group and control group. The endurance training group performed treadmill training at 70% -80% of VO2max for 8 weeks, and the static training group performed 8 weeks of anti-body weight training. Results: (1) Compared with the control group, the heart rate (heart weight / body weight) significantly increased (P <0.05) and the atrial natriuretic peptide level increased significantly (P <0.01) And NOS activity were significantly increased (P <0 05). (2) The cardiac coefficient of the static group increased significantly, and the level of angiotensin in myocardial tissue increased significantly (P <0.05). CONCLUSIONS: Exercise induces adaptive changes in cardiac endocrine hormones and endogenous nitric oxide, thereby regulating the formation of motorized heart, with changes that vary depending on the mode of exercise