论文部分内容阅读
本文收集腹腔镜或手术证实为子宫内膜异位症患者４３例，随机分成三组，分别应用丹那唑３个月，三苯氧胺３个月和三苯氧胺６个月治疗，随访治疗效果，并测定了外周静脉血血清雌二醇、孕酮水平及于宫内膜雌、孕激素受体水平。结果表明：三组治疗痛经缓解率为９０．０％～１００．０％，异位结节缩小率达４１．７％～５０．０％，受孕率为１３．３％～２８．６％。治疗后，丹那唑组血清孕酮下降（Ｐ＜０．１０），三苯氧胺３个月组血清雌二醇升高（Ｐ＜０．１０），６个月组血清雌二醇下降（Ｐ＜０．０５），对子宫内膜雌激素受体改变以丹那唑及三苯氧胺６个月组明显（Ｐ＜０．００５），孕激素受体三组均发生改变（Ｐ＜０．０１～０．００５）。结果提示：丹那唑和三苯氧胺对子宫内膜异位症有一定治疗效果，其作用机理除与抑制卵巢激素分泌有关外，可能对异位灶有直接作用。
This collection of laparoscopic or surgical confirmed endometriosis in 43 patients were randomly divided into three groups, respectively, three months of danazol, tamoxifen 3 months and tamoxifen 6 months treatment, follow-up treatment, and measured the peripheral Venous blood serum estradiol, progesterone levels and endometrial estrogen and progesterone receptor levels. The results showed that the cure rate of dysmenorrhea was 90.0% ~ 100.0%, the shrinkage rate of ectopic nodules was 41.7% ~ 50.0% and the rate of conception was 13.3% ~ 28.6%. After treatment, serum progesterone decreased (P <0.10) in the Danazol group, serum estradiol increased in the 3-month tamoxifen group (P <0.10), and serum estradiol decreased in the 6-month group .05), the changes of endometrial estrogen receptor in danazol and tamoxifen for 6 months were significantly (P <0.005), progesterone receptor were changed in all three groups (P <0.01 ~ 0.005 ). The results suggest that: Danazol and tamoxifen treatment of endometriosis have a certain effect, in addition to the mechanism of its role in inhibiting the secretion of ovarian hormone may have a direct effect on the heterotopic foci.