目的 探讨急性脑出血患者术后白细胞介素-6变化规律和作用以及与GCS的关系。方法 采用双抗体夹心ELISA法检测45例急性脑出血患者术后第1天、3天、5天、7天、10天的白细胞介素6(IL-6)的血清浓度,并且同时记录发病时GCS评分。结果 患者术后第1天IL-6水平均显著高于对照组(P<0.01),第3天呈下降趋势,第10天已基本恢复正常,且增高程度与病情程度呈正相关(r=0.01,P<0.01)。结论 血清IL-6参与了急性脑出血的病理生理过程,检测IL-6可作为判断脑组织损害程度和病情预后的一种方法。 Objective To investigate the regularity and effect of interleukin-6 in patients with acute cerebral hemorrhage and its relationship with GCS. Methods The serum concentration of interleukin 6 (IL-6) in 45 patients with acute cerebral hemorrhage on day 1, 3, 5, 7 and 10 after operation was measured by double antibody sandwich ELISA. At the same time, GCS score. Results The level of IL-6 on the first postoperative day was significantly higher than that of the control group (P <0.01), decreased on the third day and returned to normal on the 10th day, with a positive correlation with the severity of illness (r = 0.01 , P <0.01). Conclusion Serum IL-6 is involved in the pathophysiological process of acute cerebral hemorrhage. Detecting IL-6 can be used as a method to judge the degree of brain damage and prognosis.