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目的:比较分析99 Tcm-MIBI显像平面与断层扫描对鼻咽癌放化疗疗效预测价值。方法:2008-03-2011-12随机选取甘肃省肿瘤医院接受放化疗的初治鼻咽癌患者60例,放疗前后行99 Tcm-MIBI显像。显像方法为静脉推注99 Tcm-MIBI 740MBq后于1h进行单光子发射计算机断层成像/计算机断层扫描技术(single photonemission computerized tomography and computerized tomography,SPECT-CT)平面+断层扫描,图像采集完成后计算肿瘤摄取比值T/N。结果:60例患者中平面显像阳性率为61.7%(37/60),断层显像阳性率为83.3%(50/60),断层显像阳性率明显高于平面显像,差异有统计学意义,χ2=7.06,P=0.008。显像阳性患者1h平面和断层显像T/N值分别为3.21±1.2和3.6±1.8,差异有统计学意义,t=2.75,P=0.003;线性相关分析显示,两者呈正相关,r=0.834,P=0.001。各疗效组平面显像及断层显像比较差异均有统计学意义,其中平面显像,F=42.322,P=0.004;断层显像,F=42.265,P=0.006。放疗后平面和断层显像的T/N值分别为1.21±0.34和1.26±0.34,差异有统计学意义,t=13.3,P=0.003。放疗后平面和断层T/N值与放疗前平面和断层T/N值比较差异具有统计学意义,其中平面显像,F=96.491,P=0.008;断层显像,F=153.997,P=0.009。结论:99 Tcm-MIBI显像SPECT-CT断层扫描在显像容积比值及显像阳性率方面优于平面扫描,通过检测鼻咽癌患者99 Tcm-MIBI是否显像及计算T/N值对预测放疗疗效有一定的价值。
Objective: To compare the value of 99 Tcm-MIBI scintigraphy and tomography in predicting the efficacy of radiotherapy and chemotherapy for nasopharyngeal carcinoma. METHODS: From March 2008 to December 2011, 60 patients with primary nasopharyngeal carcinoma who received radiochemotherapy at Gansu Cancer Hospital were randomly selected and 99 Tcm-MIBI imaging was performed before and after radiotherapy. The imaging method was computed by single photon emission computed tomography and computerized tomography (SPECT-CT) plane + tomography after intravenous injection of 99 Tcm-MIBI 740MBq at 1 h after image acquisition. Tumor uptake ratio T/N. RESULTS: The positive rate of planar imaging was 61.7% (37/60) in 60 patients, and the positive rate of computed tomography was 83.3% (50/60). The positive rate of tomographic imaging was significantly higher than that of planar imaging. The difference was statistically significant. Significance, χ2=7.06, P=0.008. The T/N values of 1h plane and tomographic imaging in patients with positive imaging were 3.21±1.2 and 3.6±1.8, respectively, and the difference was statistically significant (t=2.75, P=0.003). Linear correlation analysis showed a positive correlation between the two, r= 0.834, P=0.001. There were significant differences in planar imaging and tomographic imaging in each treatment group, including planar imaging, F=42.322, P=0.004; tomographic imaging, F=42.265, P=0.006. The T/N values of planar and tomographic imaging after radiotherapy were 1.21±0.34 and 1.26±0.34, respectively, and the difference was statistically significant (t=13.3, P=0.003). There was a statistically significant difference between the T/N values of the plane and the tomography before radiotherapy and the T/N values of the plane and the tomography before radiotherapy, including planar imaging, F=96.491, P=0.008; tomographic imaging, F=153.997, P=0.009 . Conclusion: The 99 Tcm-MIBI imaging SPECT-CT scan is superior to the planar scan in the imaging volume ratio and the positive rate of the imaging. The 99 Tcm-MIBI imaging in patients with nasopharyngeal carcinoma is detected and the T/N value is calculated. Radiation therapy has a certain value.