论文部分内容阅读
目的探讨水飞蓟宾葡甲胺片对抗精神病药所致肝损伤的疗效及安全性。方法收集2014年1月到2015年1月在我院一致的128例服用抗精神病药物所致肝损伤患者,按照随机数字表法分为观察组(64例)和对照组(64例),观察组口服水飞蓟宾葡甲胺片,对照组口服护肝宁片。分别于治疗前、治疗后1个月、3个月、6个月检测两组患者肝功能血清酶学指标和肾功能等指标。结果两组患者治疗前肝肾功能指标,组间无明显差异(P>0.05)。治疗6个月后,两组患者总有效率比较,差异无统计学意义(P>0.05)。两组患者治疗后1个月,3个月和6个月ALT、AST、γ-GT均较治疗前降低(P<0.05),且治疗1个月、3个月观察组上述指标显著低于同时段对照组(P<0.05),但治疗6个月时,两组患者的肝功能间无明显差异(P>0.05);两组患者治疗后Cr较治疗前降低,且观察组Cr显著低于同时段对照组(P<0.05);两组患者治疗前后BUN对比,以及治疗后两组BUN组间比较,差异均无统计学意义(P>0.05)。结论相对于护肝宁片,水飞蓟宾葡甲胺片起效更快且改善作用更明显,且安全性高,值得临床推广。
Objective To investigate the efficacy and safety of silibinin meglumine tablets against liver injury induced by psychiatric drugs. Methods A total of 128 patients with liver injury caused by antipsychotics were enrolled in our hospital from January 2014 to January 2015. The patients were divided into observation group (64 cases) and control group (64 cases) according to random number table. Group oral silybin meglumine tablets, the control group oral Huganing tablets. Before and after treatment, respectively, 1 month after treatment, 3 months, 6 months to detect liver function in patients with serum enzyme and renal function indicators. Results There was no significant difference between the two groups before treatment (P> 0.05). After 6 months of treatment, the total effective rate was no significant difference between the two groups (P> 0.05). The levels of ALT, AST and γ-GT at 1 month, 3 months and 6 months after treatment in both groups were lower than those before treatment (P <0.05), and the above indexes in the observation group at 1 month and 3 months after treatment were significantly lower (P <0.05). However, there was no significant difference in liver function between the two groups at 6 months (P> 0.05). After treatment, Cr in both groups was lower than that before treatment, and Cr in the observation group was significantly lower (P <0.05). There was no significant difference in BUN between the two groups before and after treatment, and between the two groups after treatment (P> 0.05). Conclusion Compared with Huganing Tablets, silibinin meglumine tablets play a more effective role in improving and more obvious, and high safety, it is worth clinical promotion.