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目的分析阿司匹林联合他汀类药物对脑血栓患者颈动脉斑块面积及厚度的影响。方法选取脑血栓患者90例作为研究对象,将其随机分为两组,每组45例。两组均给予常规治疗,对照组在常规治疗基础上给予阿司匹林,观察组在对照组治疗基础上联合应用辛伐他汀。比较两组治疗前后三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、颈动脉内膜中层厚度(IMT)及颈动脉斑块面积。结果治疗前,两组患者血脂水平、IMT、颈动脉斑块面积比较,差异未见统计学意义(P<0.05);治疗后,观察组TG、TC、LDL-C水平、IMT及颈动脉斑块面积均低于对照组,差异有统计学意义(P<0.05);两组HDL-C水平比较差异未见统计学意义(P>0.05)。结论阿司匹林联合他汀类药物治疗脑血栓,可有效缩减患者颈动脉斑块面积及厚度,改善患者血脂水平,临床效果显著。
Objective To analyze the effect of aspirin combined with statins on carotid plaque area and thickness in patients with cerebral thrombosis. Methods Totally 90 patients with cerebral thrombosis were selected as study subjects and randomly divided into two groups (45 cases in each group). The two groups were given routine treatment, the control group was given aspirin on the basis of routine treatment, and the observation group was given simvastatin combined with the control group. The triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), carotid artery intima-media thickness (IMT) Carotid plaque area. Results Before treatment, the levels of serum lipids, IMT and carotid plaque area in two groups had no significant difference (P <0.05). After treatment, the levels of TG, TC, LDL-C, IMT and carotid plaque (P <0.05). There was no significant difference in HDL-C levels between the two groups (P> 0.05). Conclusions Aspirin combined with statins in the treatment of cerebral thrombosis can effectively reduce the carotid plaque area and thickness, and improve the level of blood lipids in patients. The clinical effect is remarkable.